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Finally, the requirement for insulin receptor/IRS in insulin resistance has been tested through independent PI3K/Akt pathway activation via PDGF receptor overexpression

In plant TyrAs, an acidic residue at the corresponding 222 position confers ADH activity by directly interacting with the side chain amine of arogenate, and when mutated to a non-acidic Asn, switches to PDH activity (Schenck et al., 2017)